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Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol by Horien, Corey ;Fontenelle, Scuddy ;Joseph, Kohrissa ;Powell, Nicole ;Nutor, Chaela ;Fortes, Diogo ;Butler, Maureen ;Powell, Kelly ;Macris, Deanna ;Lee, Kangjoo ;Greene, Abigail S. ;McPartland, James C. ;Volkmar, Fred R. ;Scheinost, Dustin ;Chawarska, Katarzyna ;Constable, R. Todd is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract Performing functional magnetic resonance imaging (fMRI) scans of children can be a difficult task, as participants tend to move while being scanned. Head motion represents a significant confound in fMRI connectivity analyses. One approach to limit motion has been to use shorter MRI protocols, though this reduces the reliability of results. Hence, there is a need to implement methods to achieve high-quality, low-motion data while not sacrificing data quantity. Here we show that by using a mock scan protocol prior to a scan, in conjunction with other in-scan steps (weighted blanket and incentive system), it is possible to achieve low-motion fMRI data in pediatric participants (age range: 7–17 years old) undergoing a 60 min MRI session. We also observe that motion is low during the MRI protocol in a separate replication group of participants, including some with autism spectrum disorder. Collectively, the results indicate it is possible to conduct long scan protocols in difficult-to-scan populations and still achieve high-quality data, thus potentially allowing more reliable fMRI findings.
Who reads Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol?
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- Author
- Horien, Corey ;Fontenelle, Scuddy ;Joseph, Kohrissa ;Powell, Nicole ;Nutor, Chaela ;Fortes, Diogo ;Butler, Maureen ;Powell, Kelly ;Macris, Deanna ;Lee, Kangjoo ;Greene, Abigail S. ;McPartland, James C. ;Volkmar, Fred R. ;Scheinost, Dustin ;Chawarska, Katarzyna ;Constable, R. Todd
- Publisher
- Springer Science and Business Media LLC
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)