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Efficacy and safety of once‐weekly semaglutide in Japanese individuals with type 2 diabetes by baseline age and body mass index by Daisuke Yabe; Yuichiro Yamada; Kohei Kaku; Tomoyuki Nishida; Toshihiro Sato; Yutaka Seino is a Medicine article available to read on EtoBox.
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## Abstract ## Aims/Introduction Many East Asians with type 2 diabetes are elderly and have a low body mass index (BMI), especially in 'super‐aged' populations, such as Japan. This post‐hoc analysis assessed once‐weekly semaglutide efficacy and safety in Japanese individuals with type 2 diabetes across baseline age and BMI subgroups. ## Materials and Methods Data were derived from the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) Japan monotherapy and SUSTAIN Japan oral antidiabetes drug (OAD) combination trials comparing once‐weekly semaglutide with sitagliptin or OADs, respectively. Participants were grouped by baseline age (<65 and ≥65 years) and/or BMI (<25 and ≥25 kg/m^2^). Reductions from baseline in glycosylated hemoglobin and bodyweight (efficacy), and adverse events (safety) were assessed. ## Results In this analysis, participants from the SUSTAIN Japan monotherapy trial (__n__ = 308; __n__ per subgroup; range, 8–73) and SUSTAIN Japan OAD combination trial (__n__ = 601; __n__ per subgroup; range, 20–168) were included. Reductions in glycosylated hemoglobin and bodyweight were numerically greater with semaglutide versus comparators across all
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- Author
- Daisuke Yabe; Yuichiro Yamada; Kohei Kaku; Tomoyuki Nishida; Toshihiro Sato; Yutaka Seino
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)