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Can I read In vitro effect of bile salts on rat liver plasma membrane, lipid fluidity, and ATPase activity on EtoBox?
In vitro effect of bile salts on rat liver plasma membrane, lipid fluidity, and ATPase activity by Bruce F. Scharschmidt; Emmet B. Keeffe; Donald A. Vessey; Nancy M. Blankenship; Robert K. Ockner is a Medicine article available to read on EtoBox.
What is In vitro effect of bile salts on rat liver plasma membrane, lipid fluidity, and ATPase activity about?
Considerable evidence suggests that liver plasma membrane (LPM) NaK-ATPase [(Na+ + K+)dependent adenosinetriphosphatase] and Mg-ATPase (Mg2+-dependent adenosinetriphosphatase) activity and lipid fluidity are important in liver cell functions such as bile formation. However, little is known regarding factors which might alter these membrane properties in uiuo. Bile salts are actively concentrated by liver cells under normal conditions and reach even higher tissue concentrations in cholestasis. Since current methodology does not permit investigation of the effect of bile salts on LPM in uiuo, we have examined the effects of bile salts in uitro on isolated rat LPM essentially free of organelle contamination and enriched 52.9-, 23.8-, and 27.8-fold in NaK-ATPase, 5'-nucleotidase, and alkaline phosphatase, respectively, compared with homogenate. We found that taurocholate (0.5 to 4.0 mM), taurochenodeoxycholate (0.25 to 4.0 mM), deoxycholate (0.25 to 4.0
Who reads In vitro effect of bile salts on rat liver plasma membrane, lipid fluidity, and ATPase activity?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Bruce F. Scharschmidt; Emmet B. Keeffe; Donald A. Vessey; Nancy M. Blankenship; Robert K. Ockner
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 1981
- Language
- EN
- Field
- Medicine (Health Sciences)