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Cancer Stem Cells and Self-renewal (Article) by Catherine Adell O'Brien, Antonija Kreso, and Catriona H.M. Jamieson is a nonfiction available to read on EtoBox.

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## Abstract The cancer stem cell (CSC) or cancer-initiating cancer (C-IC) model has garnered considerable attention over the past several years since Dick and colleagues published a seminal report showing that a hierarchy exists among leukemic cells. In more recent years, a similar hierarchical organization, at the apex of which exists the CSC, has been identified in a variety of solid tumors. Human CSCs are defined by their ability to: (i) generate a xenograft that histologically resembles the parent tumor from which it was derived, (ii) be serially transplanted in a xenograft assay thereby showing the ability to self-renew (regenerate), and (iii) generate daughter cells that possess some proliferative capacity but are unable to initiate or maintain the cancer because they lack intrinsic regenerative potential. The emerging complexity of the CSC phenotype and function is at times daunting and has led to some confusion in the field. However, at its core, the CSC model is about identifying and characterizing the cancer cells that possess the greatest capacity to regenerate all aspects of the tumor. It is becoming clear that cancer cells evolve as a result of their ability to hijack

Who reads Cancer Stem Cells and Self-renewal (Article)?

Author

Catherine Adell O'Brien, Antonija Kreso, and Catriona H.M. Jamieson

Publisher

American Association for Cancer Research; American Association for Cancer Research (AACR) (ISSN 1078-0432)

Published

2010

Language

EN

Category

nonfiction