Can I read Amphotericin B toxicity as related to the formation of oxidatively modified low-density lipoproteins on EtoBox?

Amphotericin B toxicity as related to the formation of oxidatively modified low-density lipoproteins by Joanna Barwicz; Isabelle Dumont; Claire Ouellet; Ilona Gruda is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Amphotericin B toxicity as related to the formation of oxidatively modified low-density lipoproteins about?

The effect of amphotericin B on the oxidation and degradation of low- and high-density lipoproteins was investigated by UV-vis spectroscopy, electron microscopy, electrophoresis, and size-exclusion chromatography. Two formulations of the drug were used: the commercial Fungizone and a new, less toxic, liposomal formulation, AmBisome. It was shown that Fungizone strongly enhanced the oxidative deformation of low-density lipoprotein structure while AmBisome did not bind to this lipoprotein fraction and did not affect its oxidation. It was shown that amphotericin B contained in Fungizone extracted cholesterol from low-density lipoproteins which sensitized them to oxidation. Both formulations of amphotericin B studied here did not bind to high-density lipoprotein and did not affect the process of its oxidation.

Who reads Amphotericin B toxicity as related to the formation of oxidatively modified low-density lipoproteins?

Author

Joanna Barwicz; Isabelle Dumont; Claire Ouellet; Ilona Gruda

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1075-4261)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)