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Can I read Chido-Substance in Plasma on EtoBox?
Chido-Substance in Plasma by Middleton, Janice; Crookston, Marie C. is a Medicine article available to read on EtoBox.
What is Chido-Substance in Plasma about?
The specific inhibition of anti-Chido by the plasma (and serum) of Chidopositive subjects (adult and newborn) is the basis for the Chido-substance inhibition test. This test has proved to be a reliable method for detecting Chido-negative donors, and for identifying anti-Chido. Among 639 random donors in Toronto, the plasma of 11 lacked Chido-substance (i.e., 1.7% were Chido-negative). The Chido-antigen in human plasma is thus a useful genetic marker. When red cells are tested with anti-Chido, it is difficult to distinguish Chido-negative donors from those Chido-positive donors whose red cells react weakly or not at all [3,5,7]. This difficulty can be resolved by using an inhibition test, based on the finding by Middleton that the plasma (and serum) of all Chido-positive subjects contains 'Chido-substance'. This substance is not present in the plasma of Chido-negative subjects [5]. Table I shows the reactions of anti-Chido with the red cells of five Chidopositive donors. With two examples of anti-Chido (Gur. and Smi.), donor Wa. was recorded as Chido-negative; with the other three examples of anti-Chido, Wa.'s cells reacted very weakly. However, as judged by the inhibiting effect of
Who reads Chido-Substance in Plasma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Middleton, Janice; Crookston, Marie C.
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0042-9007)
- Published
- 1972
- Language
- EN
- Field
- Medicine (Health Sciences)