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Effects of Androgen Receptor Inhibition on Kanamycin-Induced Hearing Loss in Rats by Kyung-Ju Chun; Chang-Ho Lee; Kyung-Woon Kim; So-Min Lee; So-Young Kim is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Megalin has been proposed as an endocytic receptor for aminoglycosides as well as estrogen and androgen. We aimed to investigate the otoprotective effects of antiandrogens (flutamide, FM) on kanamycin (KM)-induced hearing loss in rats. Rats were divided into four groups. The KM group was administered KM (20 mg/kg/day) for 5 days, while the FM group received FM (15 mg/kg/day) for 10 days. In the KM + FM group, KM and FM (15 mg/kg/day) were simultaneously injected for 5 days and then FM was injected for 5 days. Auditory brainstem responses were measured. Western blotting and/or quantitative reverse transcriptase-polymerase chain reaction were performed for megalin, cytochrome P450 1A1 (Cyp1a1), Cyp1b1, metallothionein 1A (MT1A), MT2A, tumor necrosis factor (TNF)-α, caspase 3, and cleaved caspase 3. The FM + KM group showed attenuated auditory thresholds when compared with the KM group at 4, 8, 16, and 32 kHz (all __p__ < 0.05). The KM + FM group showed lower megalin and Cyp1b1 levels than the KM group (all __p__ < 0.05). The KM + FM group revealed lower MT1A, TNFα, and caspase 3 protein levels, compared with those in the KM group (all __p__ < 0.05). Androgen receptor inhibition prote

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Author

Kyung-Ju Chun; Chang-Ho Lee; Kyung-Woon Kim; So-Min Lee; So-Young Kim

Publisher

MDPI AG

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)