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Molecular Mechanisms Underlying Pituitary Pathogenesis by Melanie Sapochnik; Leandro Eduardo Nieto; Mariana Fuertes; Eduardo Arzt is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Molecular Mechanisms Underlying Pituitary Pathogenesis about?

During the last years, progress has been made on the identification of mechanisms involved in anterior pituitary cell transformation and tumorigenesis. Oncogene activation, tumor suppressor gene inactivation, epigenetic changes, and microRNAs deregulation contribute to the initiation of pituitary tumors. Despite the high prevalence of pituitary adenomas, they are mostly benign, indicating that intrinsic mechanisms may regulate pituitary cell expansion. Senescence is characterized by an irreversible cell cycle arrest and represents an important protective mechanism against malignancy. Pituitary tumor transforming gene (PTTG) is an oncogene involved in early stages of pituitary tumor development, and also triggers a senescence response by activating DNA-damage signaling pathway. Cytokines, as well as many other factors, play an important role in pituitary physiology, affecting not only cell proliferation but also hormone secretion. Special interest is focused on interleukin-6 (IL-6) because its dual function of stimulating pituitary tumor cell growth but inhibiting normal pituitary cells proliferation. It has been demonstrated that IL-6 has a key role in promoting and maintenance of

Who reads Molecular Mechanisms Underlying Pituitary Pathogenesis?

Author

Melanie Sapochnik; Leandro Eduardo Nieto; Mariana Fuertes; Eduardo Arzt

Published

2015

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)