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Role of Kir4.1 channels in growth control of glia by Haruki Higashimori; Harald Sontheimer is a Neuroscience article available to read on EtoBox.
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## Abstract The inwardly rectifying potassium channel Kir4.1 is widely expressed by astrocytes throughout the brain. Kir4.1 channels are absent in immature, proliferating glial cells. The progressive expression of Kir4.1 correlates with astrocyte differentiation and is characterized by the establishment of a negative membrane potential (> −70 mV) and an exit from the cell cycle. Despite some correlative evidence, a mechanistic interdependence between Kir4.1 expression, membrane hyperpolarization, and control of cell proliferation has not been demonstrated. To address this question, we used astrocyte‐derived tumors (glioma) that lack functional Kir4.1 channels, and generated two glioma cell lines that stably express either AcGFP‐tagged Kir4.1 channels or AcGFP vectors only. Kir4.1 expression confers the same K^+^ conductance to glioma membranes and a similar responsiveness to changes in [K^+^]~o~ that characterizes differentiated astrocytes. Kir4.1 expression was sufficient to move the resting potential of gliomas from −50 to −80 mV. Importantly, Kir4.1 expression impaired cell growth by shifting a significant number of cells from the G2/M phase into the quiescent G0/G1 stage of the
Who reads Role of Kir4.1 channels in growth control of glia?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Haruki Higashimori; Harald Sontheimer
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 2007
- Language
- EN
- Field
- Neuroscience (Life Sciences)