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1) Drug-induced liver injury (DILI) is a common and often unrecognized cause of liver damage in patients receiving treatment for tuberculosis. The first line anti-tuberculosis drugs isoniazid, rifampicin, and pyrazinamide are all potentially hepatotoxic. 2) Mechanisms of anti-tuberculosis drug hepatotoxicity include direct toxicity, idiosyncratic reactions, induction of hepatic enzymes, and allergic reactions. Risk factors for DILI include age, gender, genetics, alcohol use, underlying liver disease, and

Author

FahadKamal

Language

EN