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Effect of Vitamin B Complex Treatment on Macrophages to Schwann Cells Association during Neuroinflammation after Peripheral Nerve Injury by Ehmedah, Adil; Nedeljkovic, Predrag; Dacic, Sanja; Repac, Jelena; Draskovic-Pavlovic, Biljana; VuÄeviÄ, Dragana; Pekovic, Sanja; Nedeljkovic, Biljana Bozic is a Chemistry article available to read on EtoBox.

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Peripheral nerve injury (PNI) triggers a complex multi-cellular response involving the injured neurons, Schwann cells (SCs), and immune cells, often resulting in poor functional recovery. The aim of this study was to investigate the effects of the treatment with vitamin B (B1, B2, B3, B5, B6, and B12) complex on the interaction between macrophages and SCs during the recovery period after PNI. Transection of the motor branch of the femoral nerve followed by reconstruction by termino-terminal anastomosis was used as an experimental model. Isolated nerves from the sham (S), operated (O), and operated groups treated with the B vitamins (OT group) were used for immunofluorescence analysis. The obtained data indicated that PNI modulates interactions between macrophages and SCs in a time-dependent manner. The treatment with B vitamins complex promoted the M1-to M2-macrophage polarization and accelerated the transition from the non-myelin to myelin-forming SCs, an indicative of SCs maturation. The effect of B vitamins complex on both cell types was accompanied with an increase in macrophage/SC interactions, all of which correlated with the regeneration of the injured nerve. Clearly, the ca

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Author

Ehmedah, Adil; Nedeljkovic, Predrag; Dacic, Sanja; Repac, Jelena; Draskovic-Pavlovic, Biljana; VuÄeviÄ, Dragana; Pekovic, Sanja; Nedeljkovic, Biljana Bozic

Publisher

Molecular Diversity Preservation International; MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Berlin: Springer, 1996-; Basel: 1997-; Springer Science and Business Media LLC (ISSN 1420-3049)

Published

2020

Language

EN

Field

Chemistry (Life Sciences)