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Is home-based monitoring of ovulation to time frozen embryo transfer a cost-effective alternative for hospital-based monitoring of ovulation? Study protocol of the multicentre, non-inferiority Antarctica-2 randomised controlled trial by T R Zaat; J P de Bruin; M Goddijn; M van Baal; E B Benneheij; E M Brandes; F Broekmans; A E P Cantineau; B Cohlen; J van Disseldorp; S C J P Gielen; E R Groenewoud; A van Heusden; E M Kaaijk; C Koks; C H de Koning; N F Klijn; C B Lambalk; P J Q van der Linden; P Manger; R H F van Oppenraaij; Q Pieterse; J Smeenk; J Visser; M van Wely; F Mol is a Medicine article available to read on EtoBox.

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## Abstract ## STUDY QUESTION The objective of this trial is to compare the effectiveness and costs of true natural cycle (true NC-) frozen embryo transfer (FET) using urinary LH tests to modified NC-FET using repeated ultrasound monitoring and ovulation trigger to time FET in the NC. Secondary outcomes are the cancellation rates of FET (ovulation before hCG or no dominant follicle, no ovulation by LH urine test, poor embryo survival), pregnancy outcomes (miscarriage rate, clinical pregnancy rates, multiple ongoing pregnancy rates, live birth rates, costs) and neonatal outcomes (including gestational age, birthweight and sex, congenital abnormalities or diseases of babies born). ## WHAT IS KNOWN ALREADY FET is at the heart of modern IVF. To allow implantation of the thawed embryo, the endometrium must be prepared either by exogenous oestrogen and progesterone supplementation (artificial cycle (AC)-FET) or by using the NC to produce endogenous oestradiol before and progesterone after ovulation to time the transfer of the thawed embryo (NC-FET). During an NC-FET, women visit the hospital repeatedly and receive an ovulation trigger to time FET (i.e. modified (m)NC-FET or hospital-base

Who reads Is home-based monitoring of ovulation to time frozen embryo transfer a cost-effective alternative for hospital-based monitoring of ovulation? Study protocol of the multicentre, non-inferiority Antarctica-2 randomised controlled trial?

Author

T R Zaat; J P de Bruin; M Goddijn; M van Baal; E B Benneheij; E M Brandes; F Broekmans; A E P Cantineau; B Cohlen; J van Disseldorp; S C J P Gielen; E R Groenewoud; A van Heusden; E M Kaaijk; C Koks; C H de Koning; N F Klijn; C B Lambalk; P J Q van der Linden; P Manger; R H F van Oppenraaij; Q Pieterse; J Smeenk; J Visser; M van Wely; F Mol

Published

2021

Language

EN

Field

Medicine (Health Sciences)