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Baicalein alleviates fibrosis and inflammation in systemic sclerosis by regulating B-cell abnormalities by Bo Peng; Qin Hu; Rong He; Hongping Hou; Dongyin Lian; Ying Chen; Han Li; Ling Song; Yunhang Gao; Tengfei Chen; Guangping Zhang; Jianrong Li is a Medicine article available to read on EtoBox.
What is Baicalein alleviates fibrosis and inflammation in systemic sclerosis by regulating B-cell abnormalities about?
Abstract Background Systemic sclerosis (SSc; also known as “scleroderma”) is an autoimmune disorder characterized by extensive fibrosis, vascular changes, and immunologic dysregulation. Baicalein (phenolic flavonoid derived from Scutellaria baicalensis Georgi) has been used to treat the pathological processes of various fibrotic and inflammatory diseases. In this study, we investigated the effect of baicalein on the major pathologic characteristics of SSc: fibrosis, B-cell abnormalities, and inflammation. Methods The effect of baicalein on collagen accumulation and expression of fibrogenic markers in human dermal fibroblasts were analyzed. SSc mice were produced by injecting bleomycin and treated with baicalein (25, 50, or 100 mg/kg). The antifibrotic features of baicalein and its mechanisms were investigated by histologic examination, hydroxyproline assay, enzyme-linked immunosorbent assay, western blotting and flow cytometry. Results Baicalein (5–120 μM) significantly inhibited the accumulation of the extracellular matrix and fibroblast activation in transforming growth factor (TGF)-β1- and platelet derived growth factor (PDGF)-induced human dermal fibroblasts, as evidenced by ab
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- Author
- Bo Peng; Qin Hu; Rong He; Hongping Hou; Dongyin Lian; Ying Chen; Han Li; Ling Song; Yunhang Gao; Tengfei Chen; Guangping Zhang; Jianrong Li
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)