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Protective role of electrophile-reactive glutathione for DNA damage repair inhibitory effect of dibromoacetonitrile by Yukako Komaki; Koki Suganuma; Yuko Ibuki is a Environmental Science article available to read on EtoBox.

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Dibromoacetonitrile (DBAN) is a disinfection byproduct (DBP) and linked with cancer in rodents, but the mechanism of its carcinogenicity has not been fully elucidated. We recently reported that DBAN induced inhibition of nucleotide excision repair (NER). In this study, we investigated if glutathione (GSH) is involved in the DBAN-induced inhibition of NER. Human keratinocytes HaCaT were pretreated with L-buthionine-(S,R)-sulfoximine (BSO) to deplete intracellular GSH. BSO treatment markedly potentiated the DBAN-induced NER inhibition as well as intracellular oxidation. The recruitment of NER proteins (transcription factor IIH, and xeroderma pigmentosum complementation group G) to DNA damage sites was inhibited by DBAN, which was further exacerbated by BSO treatment. Our results suggest that intracellular GSH protects cells from DBAN-induced genotoxicity including inhibition of DNA damage repair.

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Author

Yukako Komaki; Koki Suganuma; Yuko Ibuki

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Environmental Science (Physical Sciences)