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CD1d‐restricted natural killer T cells are potent targets for human immunodeficiency virus infection by Richardson Fleuridor; Brian Wilson; Runhua Hou; Alan Landay; Harold Kessler; Lena Al‐Harthi is a Immunology and Microbiology article available to read on EtoBox.

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## Summary Invariant human natural killer T cells (NKT) express a restricted T‐cell receptor (TCR) Vα24Vβ11 repertoire. These cells share both phenotypic and functional similarities between NK and T cells. Given the emerging role of NKT cells as critical cells in bridging the gap between innate and adaptive immunity, we examined their susceptibility to productive human immunodeficiency virus (HIV) infection by T‐tropic, M‐tropic, and primary isolates of HIV. We generated three human NKT cell clones (CA5, CA29, and CA31). Phenotypic characterization of these Vα24^+^ Vβ11^+^ clones indicated that they were predominately positive for CD4, CD161, HLA‐DR, CD38, CD45RO, and CD95 expression. The NKT cell clones expressed significantly more surface CCR5 molecules/cell and lower CXCR4 molecules/cell than phytohaemagglutinin‐stimulated peripheral blood mononuclear cells (PBMC). Consistent with the surface expression of CCR5 and CXCR4, the NKT clones were also selectively susceptible to HIV M‐tropic, T‐tropic, and primary isolate infection, as evaluated by both HIV p24 enzyme‐linked immunosorbent assay and intracellular staining of HIV proteins. The amount of p24 production was dependent on t

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Author

Richardson Fleuridor; Brian Wilson; Runhua Hou; Alan Landay; Harold Kessler; Lena Al‐Harthi

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)

Published

2003

Language

EN

Field

Immunology and Microbiology (Life Sciences)