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Neurologic outcome of VZV encephalitis one year after ICU admission: a multicenter cohort study by Adrien Mirouse; Romain Sonneville; Keyvan Razazi; Sybille Merceron; Laurent Argaud; Naïke Bigé; Stanislas Faguer; Pierre Perez; Guillaume Géri; Claude Guérin; Anne-Sophie Moreau; Laurent Papazian; René Robert; François Barbier; Frédérique Ganster; Julien Mayaux; Elie Azoulay; Emmanuel Canet is a Medicine article available to read on EtoBox.
What is Neurologic outcome of VZV encephalitis one year after ICU admission: a multicenter cohort study about?
## Abstract ## Background Varicella-zoster virus (VZV) is one of the main viruses responsible of acute encephalitis. However, data on the prognosis and neurologic outcome of critically ill patients with VZV encephalitis are limited. We aimed to describe the clinical features of VZV encephalitis in the ICU and to identify factors associated with a favorable neurologic outcome. We performed a multicenter cohort study of patients with VZV encephalitis admitted in 18 ICUs in France between 2000 and 2017. Factors associated with a favorable neurologic outcome, defined by a modified Rankin Score (mRS) of 0–2 1 year after ICU admission, were identified by multivariable regression analysis. ## Results Fifty-five patients (29 (53%) men, median age 53 (interquartile range 36–66)) were included, of whom 43 (78%) were immunocompromised. ICU admission occurred 1 (0–3) day after the onset of neurological symptoms. Median Glasgow Coma Score at ICU admission was 12 (7–14). Cerebrospinal fluid examination displayed a median leukocyte count of 68 (13–129)/mm^3^, and a median protein level of 1.37 (0.77–3.67) g/L. CT scan and MRI revealed brain lesions in 30% and 66% of the cases, respectively. Invas
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- Author
- Adrien Mirouse; Romain Sonneville; Keyvan Razazi; Sybille Merceron; Laurent Argaud; Naïke Bigé; Stanislas Faguer; Pierre Perez; Guillaume Géri; Claude Guérin; Anne-Sophie Moreau; Laurent Papazian; René Robert; François Barbier; Frédérique Ganster; Julien Mayaux; Elie Azoulay; Emmanuel Canet
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)