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Magnetic Resonance Imaging Detection of Rat Renal Transplant Rejection by Monitoring Macrophage Infiltration by Zhang, Yuqing; Dodd, Stephen J.; Hendrich, Kristy S.; Williams, Mangay; Ho, Chien is a Medicine article available to read on EtoBox.
What is Magnetic Resonance Imaging Detection of Rat Renal Transplant Rejection by Monitoring Macrophage Infiltration about?
## Background: A rat renal transplantation model was studied by noninvasive magnetic resonance imaging (mri) with an infusion of ultrasmall superparamagnetic iron oxide (uspio) particles to test whether the accumulation of immune cells, such as macrophages, could be detected in vivo while the kidney transplant was being rejected. ## Methods: Major histocompatibility disparate da to bn male rat renal transplantation recipients were infused with uspio particles, with magnetic resonance (mr) images acquired before, immediately after, and one day following infusion. ## Results: When the uspio infusion was on the fourth day post-transplantation, some rejecting allografts showed a decrease of mr signal intensity one day later. isografts and allografts with triple immunosuppressant treatment had no mr signal reduction. immunohistologic staining for ed1+ macrophages and cd4+ and cd8+ t cells in allogeneic transplanted kidneys indicated the accumulation of these immune cells as acute rejection occurred. morphological studies by electron microscopy confirmed the existence of iron inside the lysosomes of macrophages of rejecting kidneys, while prussian blue staining detected the presence of i
Who reads Magnetic Resonance Imaging Detection of Rat Renal Transplant Rejection by Monitoring Macrophage Infiltration?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Zhang, Yuqing; Dodd, Stephen J.; Hendrich, Kristy S.; Williams, Mangay; Ho, Chien
- Publisher
- Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)