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Copper sulfate is utilized in aquaculture for preventing and treating various fish diseases caused by protozoa and other pathogens, with recommended concentrations varying by season. It can be combined with other substances for specific treatments, such as using a 5:2 ratio of copper sulfate to ferrous sulfate for medicinal baths. Additionally, copper sulfate is effective for disinfecting fish food to control protozoan diseases during the fishing season.

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