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Changes in cannabinoid CB~1~ receptors in striatal and cortical regions of rats with experimental allergic encephalomyelitis, an animal model of multiple sclerosis by Fernando Berrendero; Antonio Sánchez; Ana Cabranes; Carmen Puerta; José A. Ramos; Antonio García-Merino; Javier Fernández-Ruiz is a Neuroscience article available to read on EtoBox.
What is Changes in cannabinoid CB~1~ receptors in striatal and cortical regions of rats with experimental allergic encephalomyelitis, an animal model of multiple sclerosis about?
## Abstract Data, initially anecdotal, but recently supported on more solid experimental evidence, suggest that cannabinoids might be beneficial in the treatment of some of the symptoms of multiple sclerosis (MS). Despite this evidence, there are no data on the possible changes in cannabinoid CB~1~ or CB~2~ receptors, the main molecular targets for the action of cannabinoids, either in the postmortem brain of patients with MS or in animal models of this disease. The present study addressed this question using the model of experimental allergic encephalomyelitis (EAE) in Lewis rats generated by inoculation of guinea pig myelin basic protein in Freund's adjuvant. After inoculation, animals were examined daily to detect the appearance of neurological signs. The first signs appeared around day 10 after inoculation, reaching the highest degree by day 13, when animals were sacrificed and their brains removed and used for analysis of CB~1~ receptor binding, mRNA levels, and activation of GTP‐binding proteins. CB~1~ receptor binding and mRNA levels were not affected in EAE rats in brain areas such as the hippocampus, limbic structures, and cerebellum. However, there was a marked decrease i
Who reads Changes in cannabinoid CB~1~ receptors in striatal and cortical regions of rats with experimental allergic encephalomyelitis, an animal model of multiple sclerosis?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Fernando Berrendero; Antonio Sánchez; Ana Cabranes; Carmen Puerta; José A. Ramos; Antonio García-Merino; Javier Fernández-Ruiz
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 2001
- Language
- EN
- Field
- Neuroscience (Life Sciences)