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Comparative Transcriptome Profiling of Amyloid Precursor Protein Family Members in the Adult Cortex by Dorothee Aydin; Mikhail A Filippov; Jakob-Andreas Tschäpe; Norbert Gretz; Marco Prinz; Roland Eils; Benedikt Brors; Ulrike C Müller is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Comparative Transcriptome Profiling of Amyloid Precursor Protein Family Members in the Adult Cortex about?
## Background The β-amyloid precursor protein (APP) and the related β-amyloid precursor-like proteins (APLPs) undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer's disease, the physiological role of APP family members and their diverse proteolytic products is still largely unknown. The secreted APPsα ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. The γ-secretase-generated APP intracellular domain (AICD) functions as a transcriptional regulator in heterologous reporter assays although its role for endogenous gene regulation has remained controversial. ## Results To gain further insight into the molecular changes associated with knockout phenotypes and to elucidate the physiological functions of APP family members including their proposed role as transcriptional regulators, we performed DNA microarray transcriptome profiling of prefrontal cortex of adult wild-type (WT), APP knockout (APP^-/-^), APLP2 knockout (APLP2^-/-^) and APPsα knockin mice (APP^α/α^) expressing solely the secreted APPsα ectodomain. Biological pathways affected by the l
Who reads Comparative Transcriptome Profiling of Amyloid Precursor Protein Family Members in the Adult Cortex?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Dorothee Aydin; Mikhail A Filippov; Jakob-Andreas Tschäpe; Norbert Gretz; Marco Prinz; Roland Eils; Benedikt Brors; Ulrike C Müller
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2164)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)