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Can I read Characterization of platelet‐reactive antibodies in children with varicella‐associated acute immune thrombocytopenic purpura (ITP) on EtoBox?
Characterization of platelet‐reactive antibodies in children with varicella‐associated acute immune thrombocytopenic purpura (ITP) by J. Fraser Wright; Victor S. Blanchette; Hong Wang; Naveen Arya; Martin Petric; John W. Semple; Wah‐Kiam Chia; John Freedman is a Medicine article available to read on EtoBox.
What is Characterization of platelet‐reactive antibodies in children with varicella‐associated acute immune thrombocytopenic purpura (ITP) about?
Biochemical analyses were performed on blood samples obtained from two children (P1, P2) who presented with acute immune thrombocytopenic purpura (ITP) following a recent varicella zoster virus (VZV) infection. Patient sera had antibodies that were reactive with normal blood‐group O platelets as measured by flow‐cytometric assay. Western blot analysis of electrophoretically separated normal blood‐group O platelets under reducing and non‐reducing conditions demonstrated that these sera were reactive with platelet antigens of ∼50 and ∼110 kD, respectively. These 50/110 kD antigens were not reactive with seven sera from acute ITP patients whose illness was not preceded by VZV infection, with serum from a patient with a prior history of VZV and no thrombocytopenia, nor with normal healthy control sera. VZV antibodies (IgG and IgM), isolated from patient sera by affinity chromatography using immobilized purified VZV glycoproteins, were found to bind to gel‐filtered autologous platelets and with normal blood‐group O platelets, as analysed by flow cytometry. No binding was observed using antibodies similarly prepared from healthy volunteer sera. To investigate their ability to sensitize p
Who reads Characterization of platelet‐reactive antibodies in children with varicella‐associated acute immune thrombocytopenic purpura (ITP)?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- J. Fraser Wright; Victor S. Blanchette; Hong Wang; Naveen Arya; Martin Petric; John W. Semple; Wah‐Kiam Chia; John Freedman
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)