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A Toxic Environment: a Growing Understanding of How Microbial Communities Affect Escherichia coli O157:H7 Shiga Toxin Expression by Erin M. Nawrocki; Hillary M. Mosso; Edward G. Dudley is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A Toxic Environment: a Growing Understanding of How Microbial Communities Affect Escherichia coli O157:H7 Shiga Toxin Expression about?

Enterohemorrhagic (EHEC) strains, including O157:H7, cause severe illness in humans due to the production of Shiga toxin (Stx) and other virulence factors. Because Stx is coregulated with lambdoid prophage induction, its expression is especially susceptible to environmental cues. Infections with Stx-producing can be difficult to model due to the wide range of disease outcomes: some infections are relatively mild, while others have serious complications. Probiotic organisms, members of the gut microbiome, and organic acids can depress Stx production, in many cases by inhibiting the growth of EHEC strains. On the other hand, the factors currently known to amplify Stx act via their effect on the -converting phage. Here, we characterize two interactive mechanisms that increase Stx production by O157:H7 strains: first, direct interactions with phage-susceptible , and second, indirect amplification by secreted factors. Infection of susceptible strains by the -converting phage can expand the Stx-producing population in a human or animal host, and phage infection has been shown to modulate virulence and Acellular factors, particularly colicins and microcins, can kill O157:H7 cells but may

Who reads A Toxic Environment: a Growing Understanding of How Microbial Communities Affect Escherichia coli O157:H7 Shiga Toxin Expression?

Author

Erin M. Nawrocki; Hillary M. Mosso; Edward G. Dudley

Publisher

American Society for Microbiology (ISSN 0099-2240)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)