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Can I read Why Do We Test Multiple Traits in Genetic Association Studies? on EtoBox?
Why Do We Test Multiple Traits in Genetic Association Studies? by Wensheng Zhu; Heping Zhang is a Mathematics article available to read on EtoBox.
What is Why Do We Test Multiple Traits in Genetic Association Studies? about?
In studies of complex disorders such as nicotine dependence, it is common that researchers assess multiple variables related to a disorder as well as other disorders that are potentially correlated with the primary disorder of interest. In this work, we refer to those variables and disorders broadly as multiple traits. The multiple traits may or may not have a common causal genetic variant. Intuitively, it may be more powerful to accommodate multiple traits in genetic traits, but the analysis of multiple traits is generally more complicated than the analysis of a single trait. Furthermore, it is not well documented as to how much power we may potentially gain by considering multiple traits. Our aim is to enhance our understanding on this important and practical issue. We considered a variety of correlation structures between traits and the disease locus. To focus on the effect of accommodating multiple traits, we examined genetic models that are relatively simple so that we can pinpoint the factors affecting the power. We conducted simulation studies to explore the performance of testing multiple traits simultaneously and the performance of testing a single trait at a time in famil
Who reads Why Do We Test Multiple Traits in Genetic Association Studies??
It is typically read by researchers, students, and practitioners in Mathematics.
- Author
- Wensheng Zhu; Heping Zhang
- Publisher
- Elsevier ; Elsevier BV; Springer Science and Business Media LLC (ISSN 1226-3192)
- Published
- 2009
- Language
- EN
- Field
- Mathematics (Physical Sciences)