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Can I read The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog on EtoBox?
The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog by Susan L. Mooberry; Rachel M. Leal; Tina L. Tinley; Hendrik Luesch; Richard E. Moore; Thomas H. Corbett is a Medicine article available to read on EtoBox.
What is The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog about?
## Abstract Symplostatin 1, an analog of dolastatin 10, was recently isolated from cyanobacteria of the genus __Symploca__. Symplostatin 1 is a potent inhibitor of cell proliferation with IC~50~ values in the low nanomolar range and it exhibits efficacy against a variety of cancer cell types. Symplostatin 1 caused the formation of abnormal mitotic spindles and accumulation of cells in metaphase at concentrations that had only minor effects on interphase microtubules. At higher concentrations, symplostatin 1 caused the loss of interphase microtubules. Cell cycle analysis revealed that symplostatin 1 caused G~2~/M arrest, consistent with its effects on mitotic spindles. Symplostatin 1 initiated the phosphorylation of Bcl‐2, formation of micronuclei and activation of caspase 3, indicating induction of apoptosis. The cellular effects of symplostatin 1 are consistent with other antimitotic tubulin‐targeting drugs. Tubulin polymerization experiments indicated that symplostatin 1 potently inhibits the assembly of purified tubulin, suggesting that tubulin may be its intracellular target. Some microtubule‐targeting agents are reported to have antiangiogenic activity and therefore the effect
Who reads The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Susan L. Mooberry; Rachel M. Leal; Tina L. Tinley; Hendrik Luesch; Richard E. Moore; Thomas H. Corbett
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)