Opening book details…
Can I read Thiamphenicol Induced Bone Marrow Suppression as a Therapy of Myeloproliferative Diseases on EtoBox?
Thiamphenicol Induced Bone Marrow Suppression as a Therapy of Myeloproliferative Diseases by P. Fröhli; Ch. Graf; K. Rhyner is a Medicine article available to read on EtoBox.
What is Thiamphenicol Induced Bone Marrow Suppression as a Therapy of Myeloproliferative Diseases about?
Sixteen patients, suffering from myeloproliferative diseases (9 polycythaemia vera, 7 primary thrombocythaemia) and 20 control subjects were treated for 14 days with 1 g of thiamphenicol per day. The effect of 40 treatment cycles was studied. The regimen resulted in lowering the haemoglobin values by 4.8% in controls (p greater than or equal to 0.001) and patients (p greater than or equal to 0.01); the reticulocyte count dropped 43% in the patient group (p greater than or equal to 0.01) and 32% in the controls (p greater than or equal to 0.05); the thrombocyte count was decreased 42% (p greater than or equal to 0.0001) vs 29% (p greater than or equal to 0.0001) in the control group. The administration of 1 g/day of thiamphenicol for a 14 day period reduced the myelopoietic activity by 40%. The decrease of all values was statistically significant. After discontinuation of thiamphenicol therapy the haematological parameters returned to the initial values within 1-2 months. The myelodepressant activity of thiamphenicol may therefore be applied to the therapy of the myeloproliferative diseases in order to reduce the risk of spontaneous haemorrhages and thrombosis.
Who reads Thiamphenicol Induced Bone Marrow Suppression as a Therapy of Myeloproliferative Diseases?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- P. Fröhli; Ch. Graf; K. Rhyner
- Publisher
- Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 1432-0584)
- Published
- 1984
- Language
- EN
- Field
- Medicine (Health Sciences)