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Systems Biology Modeling of Endothelial Cell and Macrophage Signaling in Angiogenesis in Human Diseases by Yu Zhang; Chen Zhao; Aleksander S. Popel is a book available to read on EtoBox.

What is Systems Biology Modeling of Endothelial Cell and Macrophage Signaling in Angiogenesis in Human Diseases about?

## Introduction Angiogenesis, the growth of new blood vessels from preexisting vessels, is an important biological process involved in development, growth, reproduction, and wound healing. 1e6 Angiogenesis is a highly regulated process and is tightly controlled by many cellular and molecular mediators. 7 Tissue experiencing a lack of oxygenation initiates hypoxia response via the hypoxia-inducible factor (HIF) pathway and induce angiogenesis. Endothelial cells drive and regulate angiogenesis through various processes including tipstalk cell selection, migration, proliferation, and their downstream signaling regulating vascular permeability and stability. 10e14 Macrophages are also actively involved during angiogenesis, modulating the immune and inflammatory homeostasis. Dysregulation of angiogenesis has been widely observed and implicated in the pathogenesis of various human diseases. In cancer, excessive and functionally aberrant (e.g., unorganized, leaky) tumor-associated angiogenesis is critically involved in tumor growth and metastasis. In the eye, pathological neovascularization is a major contributing factor to vision loss in many ocular diseases affecting millions worldwi

Author

Yu Zhang; Chen Zhao; Aleksander S. Popel

Publisher

Elsevier

Published

2022

Language

EN