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Diurnal Variation of Plasma Cortisol Levels in Infancy by . Mantagos; A. Moustogiannis; A.G. Vagenakis is a Medicine article available to read on EtoBox.

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## Normal children and adults show diurnal variation of plasma Cortisol levels reaching peak values around 08.00 h and lower values around 24.00 h. Despite numerous studies on diurnal variation of plasma Cortisol levels in children, the age of appearance of a circadian rhythm has not been definitely established. The purpose of this study was to investigate the development of Cortisol circadian rhythm in infancy. In seventy healthy, full-term infants, less than six months old, plasma Cortisol was measured at 10.30 h and 22.30 h. The mean ± SEM values of daytime plasma Cortisol at one to four weeks of life were 159 ± 41, 116 ± 43, 240± 54 and 456 ± 95 nmol/1 and the night-time values were 129 ± 40, 99 ± 44, 131 ± 78 and 430 ± 105 nmol/1, respectively. No statistically significant differences were found between daytime and night-time Cortisol values during the first four weeks of life. In contrast, the daytime values of plasma Cortisol were 295 ± 62 at the age of 2-3 months, 211 ± 43 at 4-5 months and 291± 31 nmol/1 at 6 months of life, and night-time values were 166 ± 52, 119 ± 35 and 109 ±21 nmol/1, respectively, which were statistically significant (p < 0.05). These data clearly in

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Author

. Mantagos; A. Moustogiannis; A.G. Vagenakis

Published

1998

Language

EN

Field

Medicine (Health Sciences)