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Can I read ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both? on EtoBox?
ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both? by Féral, Kelly (author);Jaud, Manon (author);Philippe, Céline (author);Di Bella, Doriana (author);Pyronnet, Stéphane (author);Rouault-Pierre, Kevin (author);Mazzolini, Laurent (author);Touriol, Christian (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both? about?
The unfolded protein response (UPR) is an evolutionarily conserved adaptive signaling pathway triggered by a stress of the endoplasmic reticulum (ER) lumen compartment, which is initiated by the accumulation of unfolded proteins. This response, mediated by three sensors-Inositol Requiring Enzyme 1 (IRE1), Activating Transcription Factor 6 (ATF6), and Protein Kinase RNA-Like Endoplasmic Reticulum Kinase (PERK)-allows restoring protein homeostasis and maintaining cell survival. UPR represents a major cytoprotective signaling network for cancer cells, which frequently experience disturbed proteostasis owing to their rapid proliferation in an usually unfavorable microenvironment. Increased basal UPR also participates in the resistance of tumor cells against chemotherapy. UPR activation also occurs during hematopoiesis, and growing evidence supports the critical cytoprotective role played by ER stress in the emergence and proliferation of leukemic cells. In case of severe or prolonged stress, pro-survival UPR may however evolve into a cell death program called terminal UPR. Interestingly, a large number of studies have revealed that the induction of proapoptotic UPR can also strongly co
Who reads ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both??
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Féral, Kelly (author);Jaud, Manon (author);Philippe, Céline (author);Di Bella, Doriana (author);Pyronnet, Stéphane (author);Rouault-Pierre, Kevin (author);Mazzolini, Laurent (author);Touriol, Christian (author)
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)