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What is Rare Hemoglobin Variants and Hb A1c Measurement about?

This document discusses a study that evaluated how rare hemoglobin variants affect hemoglobin A1c (Hb A1c) measurement. The study analyzed over 33,000 patient samples measured by capillary electrophoresis (CE). 15 patients were found to have rare hemoglobin variants, including Hbs A2 prime, Agenogi, and others. For 6 samples, Hb A1c was also measured by two ion-exchange HPLC methods. Only one sample detected the rare Hb variant by both HPLC methods, and none were detected by boronate affinity HPLC. Hb A1c r

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