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Biological activity and separation of a leukaemogenic virus from murine sarcoma virus-harvey (MSV-H) by Jennifer J. Harvey; June East is a Medicine article available to read on EtoBox.

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Twelve diflerent preparations of Murine Sarcoma Virus-Harvey ( M S V -H ) had leukaemogenic activity when tested in BALBIc and C,H/Bi mice or Sprague-Dawley rats, some of which ultimately developed generalized lymphocytic leukaemia instead of reacting rapidly and characteristically with sarcoma formation andlor erythroblastic splenomegaly. Inactivation of MS V-H by ether treatment, reducing its titre by dilution, and using the intramuscular route of injection, all biased towards leukaernogenesis. The leukaemogenic component could be separated by vertical transmission from thret M S V-H-infected female mice, which themselves showed only sarcomas andlor splenic erythroblastosis, to as many as six successive generations of their untreated offspring. Presence of a leukaemogenic virus, probably M L V , was confirmed by serial passage of plasma filtrates from leukaemic animals, including leukaemic progeny, in newborn mice and rats. Lymphocytic leukaemia developed exclusively in these recipients and in those given a plasma concentrate. Moreover, pre-treatment with the leukaemogenic virus enhanced the oncogenicity of MSV-H in 8-and 14-day-old mice, as judged by an increased incidence of sa

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Author

Jennifer J. Harvey; June East

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1969

Language

EN

Field

Medicine (Health Sciences)