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SOC and now also SIC: Store-operated and store-inhibited channels by Claudia Moreno; Luis Vaca is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract There is a specialized form of calcium influx that involves a close communication between endoplasmic reticulum and the channels at the plasma membrane. In one side store depletion activates channels known as store‐operated channels (SOC), which are responsible of the well‐studied store‐operated calcium entry (SOCE). SOC comprises two different types of channels. Orai, which is exclusively activated by store depletion being the channel responsible of the calcium release‐activated calcium current, and transient receptor potential canonical channel, which in contrast, is activated by store depletion only under specific conditions and carries nonselective cationic currents. On the other hand, it has been recently shown that store depletion also inhibits calcium channels. The first member identified, of what we named as store‐inhibited channels (SIC), is the L‐type voltage‐gated calcium channel. Stores control both SOC and SIC by means of the multifunctional protein STIM1. The identification of SOC and SIC opens a new scenario for the role of store depletion in the modulation of different calcium entry pathways, which may satisfy different cellular processes.© 2011 IUBMB IU

Who reads SOC and now also SIC: Store-operated and store-inhibited channels?

Author

Claudia Moreno; Luis Vaca

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; Informa UK Limited (ISSN 1521-6543)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)