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Can I read Review: Clinical in vivo multiphoton FLIM tomography on EtoBox?
Review: Clinical in vivo multiphoton FLIM tomography by König, Karsten is a Materials Science article available to read on EtoBox.
What is Review: Clinical in vivo multiphoton FLIM tomography about?
Fluorescence Lifetime Imaging (FLIM) in life sciences based on ultrashort laser scanning microscopy and time-correlated single photon counting (TCSPC) started 30 years ago in Jena/East-Germany. One decade later, first two-photon FLIM images of a human finger were taken with a lab microscope based on a tunable femtosecond Ti:sapphire laser. In 2002/2003, first clinical non-invasive twophoton FLIM studies on patients with dermatological disorders were performed using a novel multiphoton tomograph. Current in vivo two-photon FLIM studies on human subjects are based on TCSPC and focus on (i) patients with skin inflammation and skin cancer as well as brain tumors, (ii) cosmetic research on volunteers to evaluate anti-ageing cremes, (iii) pharmaceutical research on volunteers to gain information on in situ pharmacokinetics, and (iv) space medicine to study noninvasively skin modifications on astronauts during long-term space flights. Two-photon FLIM studies on volunteers and patients are performed with multiphoton FLIM tomographs using near infrared femtosecond laser technology that provide rapid non-invasive and label-free intratissue autofluorescence biopsies with picosecond temporal r
Who reads Review: Clinical in vivo multiphoton FLIM tomography?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- König, Karsten
- Publisher
- IOP Publishing; Institute of Physics Publishing (IOP) (ISSN 2050-6120)
- Published
- 2020
- Language
- EN
- Field
- Materials Science (Physical Sciences)