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Long-Term Urodynamic Effects of Finasteride in Benign Prostatic Hyperplasia: A Pilot Study by Roger S. Kirby; Justin Vale; Jenny Bryan; Kate Holmes; Judith Webb is a Medicine article available to read on EtoBox.

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A group of 69 men with bladder outflow obstruction due to benign prostatic hyperplasia (BPH) were treated in a double-blind placebo-controlled study with finasteride (Proscar), a 5a-reductase inhibitor, 5 mg or 10 mg/day, or an identical placebo for 3 months; subsequently, 20 patients received finasteride 5 mg/day in an open extension study. Ten of these patients have now com pleted 3 years of therapy and have been reevaluated with pressure/flow urody namics. In finasteride-treated patients dihydrotestosterone (DHT) declined by over 60%, remaining unchanged with placebo. Symptom scores fell in both groups of patients, maximum flow rate values decreased on placebo but improved by a mean of 1.5 ml/s in the 10-mg group and 3.3 ml/s in the 5-mg group. After 1 year of therapy, the reduction in symptom score was well main tained and the flow rate had increased by a mean of 2.7 ml/s; the mean pros tate volume was reduced by 14% and prostate-specific antigen (PSA) had declined by 28%. In the 10 patients treated for 3 years who consented to fur ther urodynamic study, the maximum urinary flow rate had improved from a mean baseline value of 8.7 ml/s to a mean of 13.8 ml/s, while maximum sub t

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Author

Roger S. Kirby; Justin Vale; Jenny Bryan; Kate Holmes; Judith Webb

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0302-2838)

Published

1993

Language

EN

Field

Medicine (Health Sciences)