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Non‐antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re‐differentiation by Paula V. Monje; Sayuri Rendon; Gagani Athauda; Margaret Bates; Patrick M. Wood; Mary Bartlett Bunge is a Neuroscience article available to read on EtoBox.
What is Non‐antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re‐differentiation about?
## Abstract The expression of myelination‐associated genes (MGs) can be induced by cyclic adenosine monophosphate (cAMP) elevation in isolated Schwann cells (SCs). To further understand the effect of known SC mitogens in the regulation of SC differentiation, we studied the response of SCs isolated from adult nerves to combined cAMP, growth factors, including neuregulin, and serum. In adult SCs, the induction of MGs by cAMP coincided with the loss of genes expressed in non‐myelin‐forming SCs and with a change in cell morphology from a bipolar to an expanded epithelial‐like shape. Prolonged treatment with high doses of cAMP‐stimulating agents, as well as low cell density, was required for the induction of SC differentiation. Stimulation with serum, neuregulin alone, or other growth factors including PDGF, IGF and FGF, increased SC proliferation but did not induce the expression of MGs or the associated morphological change. Most importantly, when these factors were administered in combination with cAMP‐stimulating agents, SC proliferation was synergistically increased without reducing the differentiating activity of cAMP. Even though the initiation of DNA synthesis and the induction
Who reads Non‐antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re‐differentiation?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Paula V. Monje; Sayuri Rendon; Gagani Athauda; Margaret Bates; Patrick M. Wood; Mary Bartlett Bunge
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 2008
- Language
- EN
- Field
- Neuroscience (Life Sciences)