About this book
Gut Metagenome and Plasma Metabolome Profiles Inolder Adults Suggest Pyruvate Metabolism as a Linkbetween Sleep Quality and Frailty by Yanni Pu & Xinhe Qi & Lili Huang & Weicheng Wu & Xiaofeng Zhou & Wei Li & Zheng Yang & Mengmeng Kong & Jie Shen & Wenhao Qi & Zhonghan Sun & Zhendong Mei & Qichu Wang & Wen Yang & Xiang Gao & Xiaofeng Wang & Zhaoqian Liu & Changzheng Yuan & Yan Zheng is a book available to read on EtoBox.
CellReports, 44 (2025) 116297. doi:10.1016/j.celrep.2025.116297SUMMARYPoor sleep quality is associated with increased frailty in older adults, but the role of the gut microbiome in this relationship remains unclear. Here, gut metagenome and plasma metabolome were profiled in 1,225 individuals aged 62–96 years. Poor sleep quality was associated with reduced abundances of potential probiotics such as Faecalibacterium prausnitzii and elevated abundances of pathobionts. A gut microbiome sleep quality index (GMSI) was developed to quantify microbial balance related to better sleep quality; higher GMSI scores were inversely associated with frailty and related clinical traits. Pyruvate metabolism emerged as a key microbial pathway linking sleep quality to frailty, with features such as F. prausnitzii abundance and microbial pyridoxal 5′-phosphate biosynthesis implicated in this connection. These findings deepen our understanding of microbiome-metabolome pathways related to sleep quality and frailty in aging and provide a valuable resource for future longitudinal and interventional studies.
- Author
- Yanni Pu & Xinhe Qi & Lili Huang & Weicheng Wu & Xiaofeng Zhou & Wei Li & Zheng Yang & Mengmeng Kong & Jie Shen & Wenhao Qi & Zhonghan Sun & Zhendong Mei & Qichu Wang & Wen Yang & Xiang Gao & Xiaofeng Wang & Zhaoqian Liu & Changzheng Yuan & Yan Zheng
- Publisher
- The Author(s)
- Published
- 2025
- Language
- EN