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Randomized Phase 2 Study of Concomitant Chemoradiotherapy Using Weekly Carboplatin/paclitaxel with or Without Daily Subcutaneous Amifostine in Patients with Locally Advanced Head and Neck Cancer by Robert Haddad; Stephen Sonis; Marshall Posner; Lori Wirth; Rosemary Costello; Patricia Braschayko; Aaron Allen; Anand Mahadevan; Jayme Flynn; Elaine Burke; Yi Li; Roy B. Tishler is a Medicine article available to read on EtoBox.

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## Abstract ## BACKGROUND: A randomized phase 2 study was performed to investigate the efficacy/toxicity of combining concomitant boost radiation and weekly carboplatin/paclitaxel with or without amifostine in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). ## METHODS: Patients with newly diagnosed, locally advanced stage III or IV SCCHN received 4 weekly doses of carboplatin (area under the curve, 1.5) and paclitaxel (45 mg/m^2^) concurrently with concomitant boost radiation consisting of 72 grays in 42 fractions over 6 weeks (every day for 18 days, twice a day for 12 days) (grading determined according to the TNM staging system). All patients were randomized to subcutaneous daily amifostine at a dose of 500 mg (Arm A) or no amifostine (Arm B). Toxicity data were collected weekly, and saliva collection was performed with and without citric acid stimulation. To evaluate the correlation between serum cytokine levels and the severity of oral mucositis, we evaluated a subset (13 patients in Arm A and 11 patients in Arm B) of subjects at baseline and then on alternate weeks. ## RESULTS: Fifty‐eight patients were enrolled, 29 in each arm. The majorit

Who reads Randomized Phase 2 Study of Concomitant Chemoradiotherapy Using Weekly Carboplatin/paclitaxel with or Without Daily Subcutaneous Amifostine in Patients with Locally Advanced Head and Neck Cancer?

Author

Robert Haddad; Stephen Sonis; Marshall Posner; Lori Wirth; Rosemary Costello; Patricia Braschayko; Aaron Allen; Anand Mahadevan; Jayme Flynn; Elaine Burke; Yi Li; Roy B. Tishler

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2009

Language

EN

Field

Medicine (Health Sciences)