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The TNFd4 allele is correlated to moderate-to-severe acute graft-versus-host disease after allogeneic stem cell transplantation by Anna Nordlander; Mehmet Uzunel; Jonas Mattsson; Mats Remberger is a Medicine article available to read on EtoBox.

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**Summary.** Certain cytokine gene polymorphisms may be associated with severe acute graft‐versus‐host disease (GVHD) after allogeneic stem cell transplantation. The present study analysed 196 patients and their donors for TNF^−308^, TNFd, IL‐10^−1064^ and IL‐10^−1082^ gene polymorphisms. Serum analysis of tumour necrosis factor‐α (TNF‐α) and interleukin 10 (IL‐10) levels during conditioning therapy was also performed. Among patients with sibling donors, the TNFd allele 4 was significantly correlated with acute GVHD grades II–IV (__P__ < 0·01). Acute GVHD grades II–IV were more common among patients homozygous for the IL‐10^−1064^ allele 13 (__P__ = 0·02). Patients homozygous for the TNF^−308^ allele (AA) correlated with higher TNF‐α serum levels during conditioning (__P__ = 0·02).

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Author

Anna Nordlander; Mehmet Uzunel; Jonas Mattsson; Mats Remberger

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

2002

Language

EN

Field

Medicine (Health Sciences)