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LncRNA FOXP4-AS1 serves as a biomarker for nasopharyngeal carcinoma diagnosis and prognosis by Lei Yao; TianTian Wang; Xinyan Wang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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This study was performed to probe the clinical significance of serum lncRNA FOXP4-AS1 in nasopharyngeal carcinoma (NPC) tumorigenesis. LncRNA FOXP4-AS1 from nasopharyngeal carcinoma patients and healthy volunteers were abstracted and converged. Quantitative real-time PCR (qRT-PCR) was used to detect the expression of FOXP4-AS1. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of FOXP4-AS1. Kaplan-Meier survival analysis and log-rank test were used to assess the patients' survival prognosis. Independent risk factors for overall survival (OS) and progression-free survival (PFS) were assessed by univariate and multivariate cox proportional hazards regression analysis. In this study, we observed that the levels of FOXP4-AS1 were significantly upregulated in nasopharyngeal carcinoma patients compared to healthy volunteers. Besides, the expression of FOXP4-AS1 was closely associated with T stage, lymph node metastasis, and clinical stage. Meanwhile, ROC analysis found that FOXP4-AS1 had diagnostic values to distinguish tumor patients from healthy volunteers. Furthermore, patients with high FOXP4-AS1 expression level had poorer OS and PFS than th

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Author

Lei Yao; TianTian Wang; Xinyan Wang

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)