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The Outermost Stratum Corneum Layer is an Effective Barrier Against Dermal Uptake of Topically Applied Micronized Titanium Dioxide by F. Pflücker; H. Hohenberg; E. Hölzle; T. Will; S. Pfeiffer; R. Wepf; W. Diembeck; H. Wenck; H. Gers‐Barlag is a Medicine article available to read on EtoBox.

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In order to help clarify the controversially discussed dermal uptake properties of micronized titanium dioxide (TiO ), we conducted extensive in vitro dermal absorption studies with ’Franz‐type’ diffusion cells on excised porcine skin. After biopsies and chemical fixation, the overall localization of TiO in the skin was analyzed by means of transmission electron microscopy (TEM). The lateral and vertical distribution of TiO within the stratum corneum (SC) was investigated by tape stripping and subsequent scanning electron microscopy (SEM) in combination with energy dispersive X‐ray analysis (EDXA). TiO was found exclusively on the outermost SC layer. The surface deposit, as displayed by TEM, featured clearly distinguishable agglomerates as well as single particles with a characteristic cubic shape and a primary particle size of about 20–50 nm. Concurrently, SEM/EDXA micrographs first showed an even distribution of TiO on the skin surface. After 10‐fold stripping, however, TiO was found to be localized only in the furrows and not on the partially removed ridges of the skin surface. SEM/EDXA micrographs of the adhesive tape strips revealed a characteristic pattern of stripped materia

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Author

F. Pflücker; H. Hohenberg; E. Hölzle; T. Will; S. Pfeiffer; R. Wepf; W. Diembeck; H. Wenck; H. Gers‐Barlag

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Springer Science and Business Media LLC; Wiley (ISSN 0142-5463)

Published

1999

Language

EN

Field

Medicine (Health Sciences)