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Tumor Spread or Siege Immunity: Dissemination to Distant Metastasis or Not by Gabriela Bindea; Bernhard Mlecnik; Jérôme Galon is a Immunology and Microbiology article available to read on EtoBox.

What is Tumor Spread or Siege Immunity: Dissemination to Distant Metastasis or Not about?

## ABSTRACT Metastasis is the leading cause of cancer mortality. We have investigated the tumor microenvironment at all metastatic cascade steps (early-metastasic dissemination, synchronous metastasis, metachronous metastasis) to delineate the impact of tumor and immune parameters to this process. Tumors with and without signs of early metastasis invasion (venous-emboli, lymphatic-invasion, perineural-invasion, collectively, VELIPI) had similar levels of inflammatory and immunosuppressive molecules. Cancer mutations, gene expression levels or chromosomal instability did not significantly differ in primary tumors from patients with or without metastasis. In contrast, tumors without early metastasis invasion were highly infiltrated with Th1 and memory T cells and were associated with a good outcome. A cytotoxic immune signature, Immunoscore and increased lymphatic vessels at the invasive margin of tumors, protected against the generation of distant metastases. The metastatic landscape was highly heterogeneous, each of the metastases of a patient bearing diverse tumor-cell clones and diverse immune-microenvironments. The Immunoscore within a random metastasis significantly predicted m

Who reads Tumor Spread or Siege Immunity: Dissemination to Distant Metastasis or Not?

Author

Gabriela Bindea; Bernhard Mlecnik; Jérôme Galon

Publisher

Taylor & Francis

Published

2021

Language

EN

Field

Immunology and Microbiology (Life Sciences)