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Therapeutic drug monitoring of albendazole: Determination of albendazole, albendazole sulfoxide, and albendazole sulfone in human plasma using nonaqueous capillary electrophoresis by Andrea Procházková; Malica Chouki; Regula Theurillat; Wolfgang Thormann is a Engineering article available to read on EtoBox.

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Therapeutic drug monitoring of albendazole: Determination of albendazole, albendazole sulfoxide, and albendazole sulfone in human plasma using nonaqueous capillary electrophoresis A nonaqueous capillary electrophoretic method (NACE) for the fast determination of plasma levels of albendazole (ABZ), albendazole sulfoxide (ABZSO), and albendazole sulfone (ABZSO 2 ) is described. The assay is based upon liquid/liquid extraction of these compounds using dichloromethane at pH 10.2 (recovery between 63 and 98%), followed by a NACE separation performed within 8 min employing a 0.036 M borate buffer (apparent pH 9.9) in a mixture of methanol and N-methylformamide (1:3) and on-column absorbance detection at 280 nm. Using 0.5 mL of plasma and extract reconstitution in 200 mL N-methylformamide, drug levels between 1.0±10 mM were found to provide linear calibration graphs. Intraday and interday imprecisions evaluated from peak area ratios (n = 5) were < 10% and < 12%, respectively. Corresponding imprecisions of detection times (n = 5) were < 1% and < 6%, respectively. The limit of detection (LOD) for ABZ, ABZSO and ABZSO 2 was 8 ́10 ±7 M. The reliability of the method developed was verified vi

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Author

Andrea Procházková; Malica Chouki; Regula Theurillat; Wolfgang Thormann

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0173-0835)

Published

2000

Language

EN

Field

Engineering (Physical Sciences)