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Can I read Interleukin-1 Is Associated with Inflammation and Structural Lung Disease in Young Children with Cystic Fibrosis on EtoBox?
Interleukin-1 Is Associated with Inflammation and Structural Lung Disease in Young Children with Cystic Fibrosis by Montgomery, Samuel T.; Dittrich, A. Susanne; Garratt, Luke W.; Turkovic, Lidija; Frey, Dario L.; Stick, Stephen M.; Mall, Marcus A.; Kicic, Anthony is a Medicine article available to read on EtoBox.
What is Interleukin-1 Is Associated with Inflammation and Structural Lung Disease in Young Children with Cystic Fibrosis about?
## Background: Little is known about the role of interleukin (il)-1 in the pathogenesis of cystic fibrosis (cf) lung disease. this study investigated the relationship between il-1 signalling, neutrophilic inflammation and structural lung changes in children with cf. ## Methods: Bronchoalveolar lavage fluid (balf) from 102 children with cf were used to determine il-1α, il-1β, il-8 levels and neutrophil elastase (ne) activity, which were then correlated to structural lung changes observed on chest computed tomography (ct) scans. ## Results: Il-1α and il-1β were detectable in bal in absence of infection, increased in the presence of bacterial infection and correlated with il-8 (p < 0.0001), neutrophils (p < 0.0001) and ne activity (p < 0.01 and p < 0.001). il-1α had the strongest association with structural lung disease (p < 0.01) in the absence of infection (uninfected: p < 0.01 vs. infected: p = 0.122). ## Conclusion: Our data associates il-1α with early structural lung damage in cf and suggests this pathway as a novel anti-inflammatory target.
Who reads Interleukin-1 Is Associated with Inflammation and Structural Lung Disease in Young Children with Cystic Fibrosis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Montgomery, Samuel T.; Dittrich, A. Susanne; Garratt, Luke W.; Turkovic, Lidija; Frey, Dario L.; Stick, Stephen M.; Mall, Marcus A.; Kicic, Anthony
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1569-1993)
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)