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Ferric‐salicylaldehyde Isonicotinoyl Hydrazone, a Synthetic Iron Chelate, Alleviates Defective Iron Utilization by Reticulocytes of the Belgrade Rat by Dr. Laura M. Garrick; Kathleen Gniecko; James E. Hoke; Attila Al-Nakeeb; Prem Ponka; Michael D. Garrick is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Ferric‐salicylaldehyde Isonicotinoyl Hydrazone, a Synthetic Iron Chelate, Alleviates Defective Iron Utilization by Reticulocytes of the Belgrade Rat about?
The Belgrade rat has a hypochromic, microcytic anemia inherited as an autosomal recessive mutation. Although transferrin binds normally to reticulocytes and internalizes normally, iron accumulation into cells and heme is much slower than normal. We have investigated the role of the transferrin cycle in this mutant by bypassing transferrin iron delivery with the iron chelate ferric salicylaldehyde isonicotinoyl hydrazone (Fe-SIH). Fe-SIH increases iron uptake into heme by Belgrade reticulocytes, restoring it almost to normal levels. This increase indicates that Fe-SIH delivers iron to a step in iron utilization that is after the Belgrade defect. Depleting reticulocytes of transferrin did not alter these observations. Failure to achieve above normal rates of iron incorporation could indicate damage due to chronic intracellular iron deficiency. Also, iron delivery by Fe-SIH restored globin synthesis to near-normal levels in Belgrade reticulocytes. The rates of glycine incorporation into porphyrin and heme in Belgrade reticulocytes incubated with Fe,-transferrin or Fe-SIH paralleled the rates of iron incorporation into heme. These data are consistent with the concept that iron availabi
Who reads Ferric‐salicylaldehyde Isonicotinoyl Hydrazone, a Synthetic Iron Chelate, Alleviates Defective Iron Utilization by Reticulocytes of the Belgrade Rat?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Dr. Laura M. Garrick; Kathleen Gniecko; James E. Hoke; Attila Al-Nakeeb; Prem Ponka; Michael D. Garrick
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 1991
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)