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Intrinsically Radiopaque Hydrogels for Nucleus Pulposus Replacement by Erik J.H. Boelen; Catharina S.J. van Hooy-Corstjens; Sjoerd K. Bulstra; André van Ooij; Lodewijk W. van Rhijn; Leo H. Koole is a Engineering article available to read on EtoBox.

What is Intrinsically Radiopaque Hydrogels for Nucleus Pulposus Replacement about?

Degeneration of the intervertebral disc is the most common cause of back pain. In case of early stage degenerative disc disease or traumatic herniations, a suitable treatment may be to replace the nucleus pulposus, preserving the annulus fibrosus. Eight new hydrogel biomaterials were prepared and studied for their potential as a nucleus replacement. The hydrogels were designed according to the following criteria: (i), they should exhibit adequate radiopacity; (ii), they should be non-cytotoxic; (iii), implantation in the dry state and subsequent swelling in situ to fill the entire nucleus cavity; (iv), after swelling they should match the physical-mechanical properties of the native nucleus. The approach was to use copolymers consisting of 2-(4 0 -iodobenzoyl)-oxoethyl methacrylate (4IEMA) and a hydrophilic building block (either N-vinyl-2-pyrrolidinone (NVP) or 2-hydroxyethyl methacrylate (HEMA)); 4 copolymers of NVP/4IEMA and 4 copolymers of HEMA/4IEMA in different compositions (5,10, 15 and 20 mol% 4IEMA). The study comprised 1 H-NMR analysis of the copolymerization reaction NVP+4IEMA. Furthermore, the copolymers were studied with respect to their swelling behavior, mechanical p

Who reads Intrinsically Radiopaque Hydrogels for Nucleus Pulposus Replacement?

Author

Erik J.H. Boelen; Catharina S.J. van Hooy-Corstjens; Sjoerd K. Bulstra; André van Ooij; Lodewijk W. van Rhijn; Leo H. Koole

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)

Published

2005

Language

EN

Field

Engineering (Physical Sciences)