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Infantile fibrosarcoma: Clinical and histologic responses to cytotoxic chemotherapy by Heidi Russell; M. John Hicks; Alison A. Bertuch; Murali Chintagumpala is a Medicine article available to read on EtoBox.

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## Abstract ## Background Infantile fibrosarcoma (IF) is a rare soft tissue sarcoma that presents either at birth or in the first year of life. Complete surgical resection is usually curative but chemotherapy may shrink the tumor to facilitate complete resection. This report describes the histologic changes and outcomes in four patients with IF treated with chemotherapy and surgical resection. ## Procedure A retrospective review was performed of patients treated between 2000 and 2007. ## Results All four patients are alive with excellent functional outcomes. The patients were diagnosed from birth up to 7 months of age; three had lower extremity tumors and one had a neck tumor. All patients received vincristine, cyclophosphamide, and actinomycin; one patient also received ifosfamide and etoposide after tumor progression. One tumor, arising from the neck, had rapid shrinkage. Two lower extremity tumors had only modest changes in dimensions but upon resection, the tumor bed contained fibrous tissue with exaggerated small caliber vessels. The fourth infant developed metastatic lesions in the central nervous system, orbits, lungs, and kidney after complete removal of the primary tumor.

Who reads Infantile fibrosarcoma: Clinical and histologic responses to cytotoxic chemotherapy?

Author

Heidi Russell; M. John Hicks; Alison A. Bertuch; Murali Chintagumpala

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2009

Language

EN

Field

Medicine (Health Sciences)