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Can I read An Approach to Solvent Screening for Crystallization of Polymorphic Pharmaceuticals and Fine Chemicals on EtoBox?
An Approach to Solvent Screening for Crystallization of Polymorphic Pharmaceuticals and Fine Chemicals by Mahmoud Mirmehrabi; Sohrab Rohani is a Chemistry article available to read on EtoBox.
What is An Approach to Solvent Screening for Crystallization of Polymorphic Pharmaceuticals and Fine Chemicals about?
It is desirable to have a systematic approach for predicting or interpreting the effect of the solvents on the production of polymorphs. A method based on the atomic electronegativity is suggested that calculates the partial charge distribution in the solute and solvent molecules. Using the calculated partial charges, correlations are developed to predict the hydrogen bonding ability of the solute and/or solvent molecules. The predictive capability of the proposed correlations is compared with the results of a quantum mechanics approach. Selection of the right solvent may play a significant role in the formation of a desirable polymorph or solvate. The most important properties of class 2 and 3 solvents of International Conference on Harmonization (ICH) for crystallization of polymorphic compounds are listed in this paper. The partial charge calculation has been used as a tool for analyzing the solvent impact on polymorphic isolation of two compounds: ranitidine hydrochloride (H 2 receptor antagonist) and stearic acid (used as excipients or in coating the tablets).
Who reads An Approach to Solvent Screening for Crystallization of Polymorphic Pharmaceuticals and Fine Chemicals?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Mahmoud Mirmehrabi; Sohrab Rohani
- Publisher
- John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)
- Published
- 2005
- Language
- EN
- Field
- Chemistry (Physical Sciences)