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Synthesis and pharmacological evaluation of new cysLT1 receptor antagonists by R Griera; M Armengol; A Reyes; M Alvarez; A Palomer; F Cabré; J Pascual; M.L. Garcia; D Mauleón is a Chemistry article available to read on EtoBox.
What is Synthesis and pharmacological evaluation of new cysLT1 receptor antagonists about?
This paper describes the synthesis and pharmacological evaluation of three series of compounds 4a-b. 13a-k and 19, structurally related to the known potent cysLT, receptor antagonists RG-12553, ICI-204219 and ONO-1078, respectively. The common structural feature of these new series is the presence of a 4-quinolone nucleus acting as a template for substitution of the aromatic nucleus present in the prototype antagonists. We describe the evolution of these series leading to antagonists with potency at nanomolar concentrations in vitro. leukotriene D, / antagonist / 4-quinolone ! acylsulfonamide / molecular modelling
Who reads Synthesis and pharmacological evaluation of new cysLT1 receptor antagonists?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- R Griera; M Armengol; A Reyes; M Alvarez; A Palomer; F Cabré; J Pascual; M.L. Garcia; D Mauleón
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 1997
- Language
- EN
- Field
- Chemistry (Physical Sciences)