About this Environmental Science article
Antagonistic effect of VDR/CREB1 pathway on cadmium-induced apoptosis in porcine spleen by Zhang Yiming; Yin Hang; Shao Bing; Xue Hua; Huang Bo; Liu Honggui; Li Shu is a Environmental Science article available to read on EtoBox.
Cadmium (Cd) is a toxic trace element that can enter the environment with industrial waste and accumulate in the body but the health effects of Cd on ternary pigs are still lacking in research. In order to explore the effect of Cd on the apoptosis of pig spleen and its mechanism, this study chose ternary pig as the research object to detect relevant indicators in pig spleen under Cd exposure. The results of this study showed that Cd exposure can induce apoptosis by promoting the absorption of various toxic trace elements in the spleen and inducing oxidative stress. We also found that the mechanism of Cd-induced apoptosis is closely related to the VDR/CREB1 pathway. On the one hand, Cd exposure can activate VDR, and indirectly regulate the CYP family, affecting the normal function of the spleen. On the other hand, VDR and its downstream genes antagonize the toxicity of Cd by maintaining the stability of the mitochondrial-related endoplasmic reticulum membrane structure. Our research will help researchers to further understand the physiological toxicity of Cd.
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Zhang Yiming; Yin Hang; Shao Bing; Xue Hua; Huang Bo; Liu Honggui; Li Shu
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Environmental Science (Physical Sciences)