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What is Cytoplasmic p21 Induced by p65 Prevents Doxorubicin-Induced Cell Death in Pancreatic Carcinoma Cell Line about?

Over-expression of p65 decreased the cytotoxic effect of DOX on pancreatic carcinoma cell line, correlating with increased induction of cytoplasmic p21. Down-regulation of p55 or p55 / p65 in the PANC1 cells were more sensitive to DOX treatment, correlated with activation of caspase-3 and clear elevation of nuclear p21 level.

Author

Tarmidi Midzi

Language

EN