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Stromal and epithelial predominant Wilms tumours have an excellent outcome: The SIOP 93 01 experience by Arnauld C. Verschuur; Gordan M. Vujanic; Harm Van Tinteren; Kathy Pritchard Jones; Jan de Kraker; Bengt Sandstedt is a Medicine article available to read on EtoBox.
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## Abstract ## Background Wilms tumour (WT) has various subtypes that are correlated with prognosis and require distinct therapy. Stromal predominant (SpWT) and epithelial WT (EpWT) have previously been associated with a good outcome. The current analysis describes the outcome and (tumour) characteristics of all patients with SpWT, EpWT, including highly differentiated epithelial type (HDET), treated according to the International Society of Pediatric Oncology (SIOP) 93‐01 study. ## Procedure All children older than 6 months and below 18 years of age with localized or metastatic WT and intermediate risk (IR) histology or HDET treated with pre‐operative chemotherapy were included in the present analysis. ## Results A total of 1,389 eligible patients had IR or HDET histology: 1% HDET, 4% EpWT, 10% SpWT, and 85% other IR. For EpWT/HDET, 93% had stage I/IIN−, 5‐year EFS was 90.2% and overall survival of (OS) 98.4%, as compared to 84.0% and 92.5% in other IR histology (NS). Stage I EpWT/HDET had a significant better outcome than stage I of other IR. In SpWT 82% of cases had stage I/IIN−; 5‐year EFS was 94.3% and OS 99.2%, significantly better compared to other IR histology. All patients
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- Author
- Arnauld C. Verschuur; Gordan M. Vujanic; Harm Van Tinteren; Kathy Pritchard Jones; Jan de Kraker; Bengt Sandstedt
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)